By M.D. Fulton Roberts

ISBN-10: 1483256758

ISBN-13: 9781483256757

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One may turn now to a consideration first of the consequences t h a t flow from Fisher's synthesis and then of the additional alleles more recently discovered. Fisher's synthesis at once simplifies and explains what might otherwise appear a complex series of reactions. I t is based on the view t h a t there are three closely-situated but independent sites on the chromosome (loci) which will receive one of each pair of alleles. The closeness of the loci, as well as their independence, can be illustrated by examining further evidence.

E. by injection or transfusion of blood or blood products containing an antigen against which the patient already possesses a naturally-occurring antibody). g. anti-tetanus inoculation) may bring about this change of character of anti-A or antiB. The antibodies displaying these new properties are referred to as " immune " anti-A or anti-B and differ from their naturally-occurring counterparts in three important ways (and several minor ways). First, their in vitro activity is greater at body-heat than at room temperature ; (the reverse is true of the naturally-occurring antibodies which in this respect are unusual serologically).

M and N are alleles for a single locus so that, as usual, one can find homozygous persons, MM or NN, or heterozygous persons, MN. 48 THE MN S SYSTEM 49 Variants of M and N are known (called M2 and N2) and one, called Mc, is thought to be intermediate between M and N (in much the same way as cv is thought to be intermediate between C and c). A recently discovered variant, called W, does not react with anti-M or anti-N. Twenty years later the discovery of a certain antiserum led to the belief that there was another locus associated with the MN one, for which the two alleles were called S and s.

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