By J. F. Nunn

ISBN-10: 0407109404

ISBN-13: 9780407109407

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Extra info for Applied Respiratory Physiology. With Special Reference to Anaesthesia

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This may occur with anxiety, fear or with very light levels of ether anaesthesia (Cobb, Converse and Landmesser, 1958), or nitrous oxide anaesthesia (Eckenhoff and Helrich, 1958). Depressant drugs displace the Pco 2/ventilation response curve to the right. In the case of opiates, there is usually little change in slope but, with general anaesthetics, the displacement is accompanied by an appreciable flattening of the curve. The degree of this change is a function of the dose of the depressant agent and itself may be represented on a dose/response curve.

Are in diffusion equilibrium with one another and there are no significant bicarbonate, chloride or hydrogen ion concentration gradients between them. It should also be noted that Cozine and Ngai (1967), working with unanaesthetized (decerebrate) cats with denervated peripheral chemoreceptors, found that apnoea did not follow the application of local anaesthetics to the central chemoreceptor areas on the antero-lateral surface of the medulla, although the minute volume of ventilation was reduced.

Apnoea was not obtained and the lowest ventilation was about 50 per cent of control at Pco 2 of about 400 mm Hg (Graham, Hill and Nunn, 1960). in Figure 8 show the progressive modifications occurring with anaesthesia of graded depth {see below). The effects of changes in P c o 2 on ventilation are also discussed in Chapter 11 (page 3 1 6 ) . The response curves above have been described in relation to arterial P c o 2. F. P c o 2 might be more appropriate and these have been shown to give particularly straight curves.

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Applied Respiratory Physiology. With Special Reference to Anaesthesia by J. F. Nunn

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