By Held L., Hofmann M.

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McColl A, Smith H, White P, Field J. General practitioner’s perceptions of the route to evidence based medicine: a questionnaire survey. Young JM, Ward JE. Evidence-based medicine in general practice: beliefs and barriers among Australian GPs. Leung AA, Ghali WA. Surveying the medical literature: five notable articles in general internal medicine from 2008 and 2009. Leung AA, Ghali WA. Appreciating the medical literature: five notable articles in general internal medicine from 2009 and 2010.

Evidence-based, pre-appraised summaries of the literature are valuable. They provide quick and reliable answers to important clinical questions. • Critical appraisal of the literature is necessary to determine the validity and importance of studies. • It is important to consider the applicability of evidence, the feasibility of an intervention, the risk–benefit ratio, and individual patient values and preferences to effectively translate evidence into patient care. REVIEW QUESTIONS 1. Which of the following resources is least likely to provide current and relevant evidence-based content?

However, with vascular injury, tissue factor activity is expressed and initiates the process of thrombin generation. Blood coagulation involves a cascade of enzymatic conversions of an enzyme precursor (zymogen) to a protease (active enzyme), which subsequently activates another zymogen. 2 Platelet Physiology and Function Blood platelets are anucleate disk-shaped cells generated by bone marrow megakaryotes. With megakaryocyte maturation, the megakaryocyte cytoplasm demar- 18╅ II╇ Hemostasis and Coagulation╅ cates into individual platelets that are shed into the circulation.

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[Article] A two-component model for counts of infectious diseases by Held L., Hofmann M.

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